Regulatory T cells essential to prevent the loss of self-tolerance in murine models of erythrocyte-specific autoantibody responses.

Abstract

The spontaneous appearance of anti-erythrocyte autoantibodies resulting in autoimmune hemolytic anemia described in NZB mice more than 40 years ago provided a model for the study of mechanisms behind the loss of self-tolerance. We developed an in vitro model of this anti-MRBC response in which CD8(+) suppressor T cells were shown to be a controlling element. CD8(+) T cells from young NZB mice co-cultured with spleen cells from old, actively autoimmune NZB mice suppressed the anti-MRBC responses of the old mice. Eliminating the CD8(+) cells from young NZB spleen cells or even from non-autoimmune BALB/c spleen cells prior to culture removed the controlling influence of these CD8(+) cells and allowed the development of anti-MRBC-secreting cells. This review will consider the role of the CD8(+) suppressive cells in the anti-self-erythrocyte model in light of insights provided by current 'regulatory T cell' literature.

• Authors: Catherine E Calkins
• Journal: Immunologic research (Immunol Res) Vol. 51 Issue 2-3 Pg. 134-44 (Dec 2011) ISSN: 1559-0755 [Electronic] United States
• PMID: 22131153 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Autoantibodies

Topics

• Anemia, Hemolytic, Autoimmune (immunology)
• Animals
• Autoantibodies (immunology)
• CD8-Positive T-Lymphocytes (immunology)
• Disease Models, Animal
• Disease Susceptibility (immunology)
• Erythrocytes (immunology)
• Humans
• Mice
• Mice, Inbred NZB
• Self Tolerance
• T-Lymphocyte Subsets (immunology)
• T-Lymphocytes, Regulatory (immunology)