Usefulness of multidisciplinary therapy combining neoadjuvant chemotherapy with S-1 plus cisplatin and postoperative sequential chemotherapy in patients with scirrhous gastric cancer.

Abstract

BACKGROUND/AIMS:

The outcomes of patients with scirrhous gastric cancer (SGC) remain poor. We retrospectively compared outcomes according to historically different treatments for SGC and studied the therapeutic usefulness of NAC with S-1 plus cisplatin followed by postoperative sequential chemotherapy.

METHODOLOGY:

We studied 93 patients with SGC. Between 1995 and 2000, 29 patients did not receive NAC and were instead given conventional anti-cancer drugs. Between 2000 and 2003, 20 patients received 4 weeks of NAC with low-dose cisplatin plus 5-fluorouracil (5-FU) followed by postoperative sequential treatment with new anticancer agents (neoadjuvant low-dose FP group). Between 2003 and 2006, 44 patients received 2 courses of NAC with S-1+cisplatin followed by postoperative sequential administration of new anticancer agents (neoadjuvant S-1+cisplatin group). Response rates and overall survival were compared among the treatment groups.

RESULTS:

The rates of response to NAC were 15% in the neoadjuvant low-dose FP group and 36% in the neoadjuvant S-1+cisplatin group. Overall survival was significantly longer in the neoadjuvant S-1+cisplatin group than the other groups.

CONCLUSIONS:

Our results suggest that multidisciplinary therapy combining NAC with S-1+cisplatin and postoperative sequential administration of new anticancer drugs is therapeutically useful in patients with SGC.

• Authors: Takashi Oshima, Chikara Kunisaki, Tsutomu Sato, Roppei Yamada, Shoichi Fujii, Yasushi Rino, Munetaka Masuda, Toshio Imada
• Journal: Hepato-gastroenterology (Hepatogastroenterology) 2012 Jul-Aug Vol. 59 Issue 117 Pg. 1638-42 ISSN: 0172-6390 [Print] Greece
• PMID: 22115800 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Drug Combinations
• Taxoids
• S 1 (combination)
• Tegafur
• Docetaxel
• Oxonic Acid
• Irinotecan
• Paclitaxel
• Cisplatin
• Fluorouracil
• Camptothecin

Topics

• Adenocarcinoma, Scirrhous (therapy)
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Camptothecin (administration & dosage, analogs & derivatives)
• Chemotherapy, Adjuvant
• Cisplatin (administration & dosage)
• Docetaxel
• Drug Combinations
• Female
• Fluorouracil (administration & dosage)
• Gastrectomy
• Humans
• Irinotecan
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Neoadjuvant Therapy
• Neoplasm, Residual
• Oxonic Acid (administration & dosage)
• Paclitaxel (administration & dosage)
• Retrospective Studies
• Stomach Neoplasms (therapy)
• Taxoids (administration & dosage)
• Tegafur (administration & dosage)