Abstract | BACKGROUND: METHODS: Patients with a histological diagnosis of collagenous colitis and lymphocytic colitis were identified through the Department of Pathology database and the IBD practice database. Patients refractory to medical treatment and with severe symptoms were offered anti-TNF therapy. RESULTS: Five of 372 MC patients (1.3%; 95% CI, 0.6 to 3.1) presented with severe symptoms refractory to standard medical therapies. One patient was denied therapy from her insurance carrier. The other 4 received infliximab therapy. The response was excellent after one dose experiencing a 60-90% decrease in bowel movements. Three patients were switched to adalimumab (2 allergic reactions and 1 early loss of response to infliximab). Long-term clinical remission (more than 1 year) was achieved in three cases (2 with adalimumab and 1 with infliximab). One patient on adalimumab had an early loss of response and was referred for colectomy. CONCLUSIONS:
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Authors | Maria Esteve, Uma Mahadevan, Empar Sainz, Elena Rodriguez, Antonio Salas, Fernando Fernández-Bañares |
Journal | Journal of Crohn's & colitis
(J Crohns Colitis)
Vol. 5
Issue 6
Pg. 612-8
(Dec 2011)
ISSN: 1876-4479 [Electronic] England |
PMID | 22115383
(Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Copyright | Copyright © 2011 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Anti-Inflammatory Agents
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Humanized
- Tumor Necrosis Factor Inhibitors
- Infliximab
- Adalimumab
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Topics |
- Adalimumab
- Anti-Inflammatory Agents
(therapeutic use)
- Antibodies, Monoclonal
(therapeutic use)
- Antibodies, Monoclonal, Humanized
(therapeutic use)
- Colitis, Collagenous
(drug therapy, pathology)
- Colitis, Lymphocytic
(drug therapy, pathology)
- Female
- Humans
- Infliximab
- Middle Aged
- Treatment Outcome
- Tumor Necrosis Factor Inhibitors
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