Plant-derived elements used for pharmacological applications constitute an increasing research field. Centella asiatica is widely used mainly as an extract (
TECA). Triterpenic fractions, the primary constituents of Centella asiatica, produce a wide range of preventive and
therapeutic effects. The modulation of
collagen production and deposition in wound healing is of primary importance.
TECA is also used to treat several microcirculatory problems, inflammatory skin conditions (
leprosy, lupus,
varicose ulcers,
eczema, atopic dermatitis,
psoriasis) and also intestinal problems,
fever,
amenorrhea and genitourinary conditions. Cognitive functions, anxiety and mental impairment may be also affected by
TECA administration. New applications in neurology include
nerve growth factor enhancement and applications in neurological degenerative conditions. Interaction with other products is also indicated in this document. The multiplicity of actions of
TECA is associated to six important mechanisms, all inter-connected and modulating each other: 1)
edema - and capillary filtration - control; 2) a strong
antioxidant power, effective on several forms of oxidative stress associated to
inflammation or
infections and synergic with other
antioxidant products; 3) an anti-inflammatory action; 4) a modulation of the
collagen production avoiding slower
scarring or faster, hyperthrophic
scarring and cheloids; 5) a modulating action of local
growth factors; 6) a modulation of angiogenesis. This "status" paper - resulting from an expert meeting held in Cobham, Surrey, indicates most of the therapeutic potential of
TECA, still to be explored in further studies. The status paper constitutes the basis for a consensus document on
TECA to be developed in the next future. This "status" paper opens a new window on an ancient but still partially unexplored product that may become an important value in prevention and treatment of several pre-clinical and risk conditions and in clinically significant disease both as a single products and in association with other 'natural' products.