The model of
type 2 diabetes mellitus in rats was established by injecting
streptozotocin from tail vein and feeding with high fat and high caloric diet. Diabetic rats were randomly divided into model group,
Jiaotai pill 1 group (Coptidis Rhizoma-cinnamon 2: 1),
Jiaotai pill 2 group (Coptidis Rhizoma-cinnamon 4: 1),
Jiaotai pill 3 group (Coptidis Rhizoma-cinnamon 10: 1) and
metformin group. Rats in different treatment groups were given by corresponding
therapy from gastric tube. Meanwhile normal control group was another set.
Body weight, oral
glucose tolerance test (OGTT), blood
lipid level including total
cholesterol (TC),
triglyceride (TG),
high density lipoprotein-cholesterol (HDL-C) and
low density lipoprotein-cholesterol (
LDL-C), plasma levels of
free fatty acid (FFA) and
adiponectin, plasma liver
enzymes activity(ALT, AST, AKP, gamma-GT) and pathological results of liver tissue were determined after eight weeks.
RESULT:
Body weight, fasting plasma
glucose (FPG), postpradial plasma
glucose at one hour (PG-1 h), postpradial
blood glucose at two hour (PG-2 h), plasma levels of TC, TG,
LDL-C, FFA and liver
enzymes activity were all increased in rats of model group compared with those in normal control group. Plasma levels of HDL-C and
adiponectin were decreased in model group (P < 0.01). Fatty degeneration of hepatocytes was apparent in liver tissues in rats of model group. Compared with model group results of OGTT, blood
lipid levels and liver
enzymes activity were improved while levels of HDL-C and
adiponectin were increased in rats of different treatment groups (P < 0.05 or P < 0.01). Meanwhile fatty degeneration of hepatocytes was improved in liver tissues in rats of different treatment groups. Compared with
metformin group, plasma level of HDL-C was elevated while AKP and gamma-GT were decreased significantly in rats of
Jiaotai pill 1 group (P < 0.05), gamma-GT level was decreased significantly in rats of
Jiaotai pill 2 group (P < 0.05), AST, AKP and gamma-GT levels were decreased significantly in rats of
Jiaotai pill 3 group (P < 0.05). Compared with
Jiaotai Pill 1 group, plasma levels of HDL-C was decreased while AKP levels was elevated significantly in rats of
Jiaotai pill 2 group, but HDL-C was decreased in rats of
Jiaotai pill 3 group (P < 0.05).
CONCLUSION: