Plasma tau protein in comatose patients after cardiac arrest treated with therapeutic hypothermia.
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| Abstract | BACKGROUND: Neurological outcome after cardiac arrest (CA) is difficult to predict in the acute phase. In this pilot study, we assessed blood levels of tau protein as a prognostic marker for the neurological outcome after 6 months in patients treated with hypothermia after resuscitation from CA. METHODS: 22 unconscious patients resuscitated after CA were treated with mild hypothermia (32-34°C) for 26 h. Blood samples were collected at 2, 6, 12, 24, 48, and 96 h after CA, and the concentration of tau protein was analyzed. Neurological outcome was assessed with the Glasgow-Pittsburgh cerebral performance category (CPC) scale at intensive care unit (ICU) discharge and after 6 months. The higher of the two CPC scores was used. RESULTS: At ICU discharge, 21/22 patients were alive, of whom 10 had a good (CPC 1-2) outcome. After 6 months, 15/22 patients were alive, of whom 14 had a good outcome. Tau protein levels were higher among those with a poor outcome at 48 h and 96 h. At 96 h sampling, tau concentration predicted a poor outcome (CPC 3-5) with a sensitivity of 71% and a specificity of 93%. CONCLUSIONS: Although in a pilot study, a late increase in plasma tau protein seems to be associated with a worse outcome after hypothermia treatment after CA, although more studies are needed.
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| Authors | E Mörtberg, H Zetterberg, J Nordmark, K Blennow, C Catry, H Decraemer, E Vanmechelen, S Rubertsson |
| Journal | Acta anaesthesiologica Scandinavica (Acta Anaesthesiol Scand) Vol. 55 Issue 9 Pg. 1132-8 (Oct 2011) ISSN: 1399-6576 [Electronic] England |
| PMID | 22092212 (Publication Type: Journal Article) |
| Copyright | 2011 The Authors. Acta Anaesthesiologica Scandinavica, 2011 The Acta Anaesthesiologica Scandinavica Foundation. |
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