Risk factors of cardiac troponin T elevation in patients with stable coronary artery disease after elective coronary drug-eluting stent implantation.

Abstract

BACKGROUND:

Cardiac troponin T elevation after coronary intervention has been demonstrated to be associated with the prognosis of coronary artery disease (CAD). However, there were few studies about comprehensive risk factors analysis of troponin T elevation after elective drug-eluting stent (DES) implantation.

HYPOTHESIS:

The prognosis of CAD after coronary interventions was associated with clinical and procedural risk factors of CAD, such as age, hypertension, severity extent of CAD and so on.

METHODS:

From March to December in 2010, patients with stable CAD were admitted for elective coronary intervention in our hospital. They were divided into an elevated troponin T group and a normal troponin T group by postprocedural troponin T. Clinical factors, laboratory-test factors, and angiographic factors (such as gender, age, cholesterol, Gensini score, and others) were analyzed.

RESULTS:

A total of 209 patients with an average age of 64.0 ± 9.9 years were enrolled in the study: 70 patients with elevated troponin T (≥0.03 ng/mL) after DES implantation and 139 patients with normal troponin T (<0.03 ng/mL). After univariate analysis, we found that age, hypertension, total cholesterol, low density lipoprotein-cholesterol (LDL-C), Gensini score, number of stenosed vessels, and total implanted stents were associated with postprocedural troponin T elevation. According to the results of multivariate analysis, we found that age, total cholesterol, number of stenosed vessels, and number of implanted stents were independent risk factors of postprocedural troponin T elevation.

CONCLUSIONS:

Age, serum total cholesterol, number of stenosed vessels, and number of implanted stents could be independent risk factors of troponin T elevation after elective DES implantation.

• Authors: Zhang-Wei Chen, Ju-Ying Qian, Jian-Ying Ma, Lei Ge, Jun-Bo Ge
• Journal: Clinical cardiology (Clin Cardiol) Vol. 34 Issue 12 Pg. 768-73 (Dec 2011) ISSN: 1932-8737 [Electronic] United States
• PMID: 22083940 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2011 Wiley Periodicals, Inc.

Chemical References

• Troponin T

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Coronary Angiography
• Coronary Artery Disease (blood, therapy)
• Drug-Eluting Stents (adverse effects)
• Female
• Humans
• Male
• Middle Aged
• Multivariate Analysis
• Prognosis
• Risk Factors
• Treatment Outcome
• Troponin T (blood)
• Young Adult