MicroRNA regulation in cancer-associated fibroblasts.

Abstract

The microenvironment of cancer cells has proven to be a critical component of tumors that strongly influences cancer development and progression into invasive and metastatic disease. Compared to normal tissue, dramatic differences in gene expression occur in multiple cell types that constitute the tumor microenvironment including cancer-associated fibroblasts (CAFs) that are important stromal components of growing tumors. In this review, we present recent advances in understanding how microRNAs are deregulated in cancer-associated fibroblasts (CAFs) and how this affects tumor biology. The microRNA signature of CAFs is discussed with respect to their functional relevance to tumor cells as well as other cell types involved in tumor homeostasis.

• Authors: Olga Aprelikova, Jeffrey E Green
• Journal: Cancer immunology, immunotherapy : CII (Cancer Immunol Immunother) Vol. 61 Issue 2 Pg. 231-237 (Feb 2012) ISSN: 1432-0851 [Electronic] Germany
• PMID: 22083346 (Publication Type: Journal Article, Research Support, N.I.H., Intramural, Review)

Chemical References

• MicroRNAs

Topics

• Animals
• Fibroblasts (metabolism, pathology)
• Gene Expression Regulation, Neoplastic
• Humans
• MicroRNAs (genetics)
• Neoplasms (genetics, pathology)
• Stromal Cells (metabolism, pathology)
• Tumor Escape