Use of alcohol-free antimicrobial mouth rinse is associated with decreased incidence of preterm birth in a high-risk population.

Abstract

OBJECTIVE:

We sought to determine if treatment of periodontal disease during pregnancy with an alcohol-free antimicrobial mouth rinse containing cetylpyridinium chloride impacts the incidence of preterm birth (PTB) in a high-risk population.

STUDY DESIGN:

This single-blind clinical trial studied pregnant women (6-20 weeks' gestation) with periodontal disease who refused dental care. Subjects receiving mouth rinse were compared to designated controls who did not receive rinse (1 rinse:2 controls), balanced on prior PTB and smoking. Primary outcome was PTB <35 weeks.

RESULTS:

In all, 226 women were included in the analysis (71 mouth rinse subjects, 155 controls). Incidence of PTB <35 weeks was lower in the rinse group compared to controls (5.6% and 21.9% respectively, P < .01); relative risk was 0.26 (95% confidence interval, 0.096-0.70). Gestational age and birthweight were significantly higher in the rinse group (P < .01).

CONCLUSION:

A nonalcohol antimicrobial mouth rinse containing cetylpyridinium chloride was associated with decreased incidence of PTB <35 weeks.

• Authors: Marjorie Jeffcoat, Samuel Parry, Robert W Gerlach, Matthew J Doyle
• Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 205 Issue 4 Pg. 382.e1-6 (Oct 2011) ISSN: 1097-6868 [Electronic] United States
• PMID: 22083060 (Publication Type: Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Mosby, Inc. All rights reserved.

Chemical References

• Anti-Infective Agents
• Mouthwashes

Topics

• Adult
• Anti-Infective Agents (administration & dosage)
• Female
• Humans
• Incidence
• Mouthwashes (therapeutic use)
• Periodontal Diseases (complications, drug therapy)
• Pregnancy
• Premature Birth (epidemiology, etiology, prevention & control)
• Risk Factors
• Single-Blind Method
• Young Adult