Abstract | BACKGROUND: AIM: To examine the effects of administration of mifepristone alone or with EE on ovarian function and cervical mucus consistency in women using Implanon. STUDY DESIGN: RESULTS: Following mifepristone intake, there was a dramatic increase in E(2) levels ranging from 543 to 1183 pmol/L (p=.000), which was not correlated with maximal follicle size or preceded by LH or FSH increase. The increase in E(2) triggered an LH increase resulting in development of a luteinized follicle in four women with no evidence of ovulation. One of these women had estradiol and progesterone levels suggestive of ovulation, but no corpus luteum was seen. Almost all women had very low mucus scores, which did not correlate with E(2) levels. DISCUSSION: Despite a transient increase in E(2) levels after mifepristone, there was no evidence of subsequent ovulation irrespective of whether they also received EE. The mechanism by which mifepristone in the presence of etonogestrel results in a rapid increase in E(2) levels remains unclear and could not be related to any significant changes in FSH, LH, ovarian follicle dynamics or subsequent possible ovulation. CONCLUSION:
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Authors | Edith Weisberg, Horatio B Croxatto, John K Findlay, Henry G Burger, Ian S Fraser |
Journal | Contraception
(Contraception)
Vol. 84
Issue 6
Pg. 600-8
(Dec 2011)
ISSN: 1879-0518 [Electronic] United States |
PMID | 22078189
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier Inc. All rights reserved. |
Chemical References |
- Contraceptive Agents, Female
- Drug Implants
- etonogestrel
- Mifepristone
- Ethinyl Estradiol
- Estradiol
- Desogestrel
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Topics |
- Adolescent
- Adult
- Cervix Mucus
(chemistry, drug effects)
- Contraceptive Agents, Female
(administration & dosage, adverse effects, antagonists & inhibitors)
- Desogestrel
(administration & dosage, adverse effects, antagonists & inhibitors)
- Double-Blind Method
- Drug Implants
- Drug Interactions
- Drug Therapy, Combination
(adverse effects)
- Estradiol
(blood)
- Ethinyl Estradiol
(administration & dosage, adverse effects, therapeutic use)
- Female
- Humans
- Luteinization
(drug effects)
- Menstrual Cycle
(blood, drug effects)
- Middle Aged
- Mifepristone
(administration & dosage, adverse effects, therapeutic use)
- Ovary
(diagnostic imaging, drug effects, physiology)
- Ovulation Inhibition
(blood, drug effects)
- Ultrasonography
- Uterine Hemorrhage
(blood, chemically induced, prevention & control)
- Viscosity
- Young Adult
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