[Clinical study of levofloxacin 500 mg qd in the treatment of cervicitis and intrauterine infections caused by Chlamydia trachomatis].

Abstract

The clinical efficacy and safety of levofloxacin (LVFX) 500mg qd were evaluated in female patients with cervicitis with Chlamydia trachomatis and intrauterine infections. LVFX was administered orally at 500 mg qd for 7 days. Bacteriological efficacy was 94.4% (17/18) and clinical efficacy was 100% (16/16) at 14 to 21 days after the end of treatment in cervicitis. On the other hand, bacteriological efficacy and clinical efficacy at the end of treatment in intrauterine infections were 68.8% (11/16) and 94.7% (18/19), respectively. For safety, adverse drug reactions occurred in 9 of 43 patients (20.9%), i.e., increased y-GTP in 2 patients, glucose urine present in 2, and each of all other adverse reactions occurred in 1. All adverse drug reactions observed were either mild or moderate. Results suggested that LVFX 500 mg qd was effective and safe in the treatment of cervicitis with Chlamydia trachomatis and intrauterine infections.

• Authors: Hiroshige Mikamo, Yuka Yamagishi, Keiichi Takahashi, Koji Izumi, Shinji Hoshina, Ken Nakabe, Michihisa Fujiwara, Makoto Yoshimura, Yukiko Ando, Motoko Kurashima, Chisato Kinoshita, Masuo Yoshioka
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 64 Issue 4 Pg. 217-29 (Aug 2011) ISSN: 0368-2781 [Print] Japan
• PMID: 22066346 (Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study)

Chemical References

• Anti-Bacterial Agents
• Levofloxacin
• Guanosine Triphosphate
• Ofloxacin

Topics

• Administration, Oral
• Adult
• Anti-Bacterial Agents (administration & dosage, adverse effects)
• Chlamydia Infections
• Chlamydia trachomatis (isolation & purification)
• Drug Administration Schedule
• Endometritis (drug therapy, microbiology)
• Female
• Glycosuria (chemically induced)
• Guanosine Triphosphate (blood)
• Humans
• Levofloxacin
• Ofloxacin (administration & dosage, adverse effects)
• Product Surveillance, Postmarketing
• Treatment Outcome
• Uterine Cervicitis (drug therapy, microbiology)
• Young Adult