Hypocellular acute myeloid leukemia in adults: analysis of the clinical outcome of 123 patients.
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| Abstract | BACKGROUND: The hypocellular variant of acute myeloid leukemia accounts for less than 10% of all cases of adult acute myeloid leukemia. It is defined by having less than 20 percent of cellular bone marrow in a biopsy at presentation. It is unclear in the literature whether the outcome of hypocellular acute myeloid leukemia differs from that of non-hypocellular acute myeloid leukemia. DESIGN AND METHODS: We retrospectively analyzed all the cases reported to be hypocellular acute myeloid leukemia between 2000 and 2009. A second pathology review was conducted and the diagnosis was confirmed in all cases. RESULTS: One hundred twenty-three (9%) patients were identified: patients with hypocellular acute myeloid leukemia were older than those with non-hypocellular acute myeloid leukemia (P=0.009) and more frequently presented with cytopenias (P<0.001). Forty-one patients with hypocellular acute myeloid leukemia had an antecedent hematologic disorder and 11 patients had received prior chemo-radiotherapy for non-hematopoietic neoplasms. On multivariate analysis, overall survival, remission duration and event-free survival were comparable to those of other patients with acute myeloid leukemia. CONCLUSIONS: The outcome of hypocellular acute myeloid leukemia does not differ from that of non-hypocellular acute myeloid leukemia.
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| Authors | Aref Al-Kali, Sergej Konoplev, Erpei Lin, Tapan Kadia, Stefan Faderl, Farhad Ravandi, Mohamad Ayoubi, Mark Brandt, Jorge E Cortes, Hagop Kantarjian, Gautam Borthakur |
| Journal | Haematologica (Haematologica) Vol. 97 Issue 2 Pg. 235-40 (Feb 2012) ISSN: 1592-8721 [Electronic] Italy |
| PMID | 22058194 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't) |
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