Abstract |
Selenium (Se) is known to regulate tumorigenesis and immunity at the nutritional and supranutritional levels. Because the immune system provides critical defenses against cancer and the athymic, immune-deficient NU/J nude mice are known to gradually develop CD8(+) and CD4(+) T cells, we investigated whether B and T cell maturation could be modulated by dietary Se and by tumorigenesis in nude mice. Fifteen homozygous nude mice were fed a Se-deficient, Torula yeast basal diet alone (Se-) or supplemented with 0.15 (Se+) or 1.0 (Se++) mg Se/kg (as Na(2)SeO(4)) for 6 months, followed by a 7-week time course of PC-3 prostate cancer cell xenograft (2 × 10(6) cells/site, 2 sites/mouse). Here, we show that peripheral B cell levels decreased in nude mice fed the Se - or Se++ diet and the CD4(+) T cell levels increased in mice fed the Se++ diet. During the PC-3 cell tumorigenesis, dietary Se status did not affect peripheral CD4(+) or CD8(+) T cells in nude mice whereas mice fed with the Se++ diet appeared to exhibit greater peripheral CD25(+)CD4(+) T cells on day 9. Dietary Se status did not affect spleen weight in nude mice 7 weeks after the xenograft. Spleen weight was associated with frequency of peripheral CD4(+), but not CD8(+) T cells. Taken together, dietary Se at the nutritional and supranutritional levels regulates peripheral B and T cells in adult nude mice before and after xenograft with PC-3 prostate cancer cells.
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Authors | Wen-Hsing Cheng, Alexandra Holmstrom, Xiangdong Li, Ryan T Y Wu, Huawei Zeng, Zhengguo Xiao |
Journal | Biological trace element research
(Biol Trace Elem Res)
Vol. 146
Issue 2
Pg. 230-5
(May 2012)
ISSN: 1559-0720 [Electronic] United States |
PMID | 22020772
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- B-Lymphocytes
(drug effects, immunology)
- CD4-Positive T-Lymphocytes
(drug effects, immunology)
- CD8-Positive T-Lymphocytes
(drug effects, immunology)
- Cell Line, Tumor
- Dietary Supplements
- Humans
- Male
- Mice
- Mice, Nude
- Neoplasm Transplantation
- Organ Size
(drug effects)
- Prostatic Neoplasms
(immunology, pathology)
- Selenium
(administration & dosage, pharmacology)
- Spleen
(drug effects, immunology, pathology)
- T-Lymphocytes
(drug effects, immunology)
- Time Factors
- Transplantation, Heterologous
- Tumor Burden
(drug effects)
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