Association of pyruvate dehydrogenase kinase 4 gene polymorphisms with type 2 diabetes and metabolic syndrome.

Abstract

AIMS:

Pyruvate dehydrogenase kinase 4 (PDK4) plays a crucial role in glucose utilization and lipid metabolism by regulating the pyruvate dehydrogenase complex (PDC) and is an emerging therapeutic target for type 2 diabetes. To date, no study has specifically examined the relationship between PDK4 gene polymorphisms and type 2 diabetes or metabolic syndrome.

METHODS:

The association of common single nucleotide polymorphisms (SNPs) was examined in PDK4 [-208A/G (rs10085637), IVS3+192C/T (rs3779478), IVS6+31A/G (rs2301630), IVS7+514A/G (rs12668651), IVS10+75C/T (rs10247649)] with type 2 diabetes and metabolic syndrome in 651 Korean subjects with type 2 diabetes and 350 nondiabetic Korean subjects. The association of these SNPs with clinical parameters related to metabolic syndromes including obesity, hyperglycemia, hypertension, and dyslipidemia was also examined.

RESULTS:

No significant association was found between the studied SNPs and type 2 diabetes, metabolic syndrome, or clinical parameters. The PDK4 gene haplotype ACAGC showed a modest association with type 2 diabetes. However, the significance of this association was lost after considering for multiple comparisons.

CONCLUSIONS:

PDK4 polymorphisms may not be associated with type 2 diabetes or metabolic syndrome. Further studies utilizing a larger study population are required to confirm these results.

• Authors: Seong-Su Moon, Jung-Eun Lee, Young-Sil Lee, Su-Won Kim, Nam Ho Jeoung, In-Kyu Lee, Jung-Guk Kim
• Journal: Diabetes research and clinical practice (Diabetes Res Clin Pract) Vol. 95 Issue 2 Pg. 230-6 (Feb 2012) ISSN: 1872-8227 [Electronic] Ireland
• PMID: 22019269 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• PDK4 protein, human
• Pyruvate Dehydrogenase Acetyl-Transferring Kinase
• Protein Serine-Threonine Kinases

Topics

• Aged
• Asian People (genetics)
• Diabetes Mellitus, Type 2 (epidemiology, genetics)
• Dyslipidemias (genetics)
• Female
• Genotype
• Humans
• Hyperglycemia (genetics)
• Hypertension (genetics)
• Male
• Metabolic Syndrome (epidemiology, genetics)
• Middle Aged
• Obesity (genetics)
• Polymorphism, Single Nucleotide
• Protein Serine-Threonine Kinases (genetics)
• Pyruvate Dehydrogenase Acetyl-Transferring Kinase
• Republic of Korea (epidemiology)