Abstract | BACKGROUND: METHODS: The relationship between Fuc-Hpt levels and clinical parameters was investigated in 77 patients with CRC, all of whom underwent primary resection. Serum Fuc-Hpt levels were examined in athymic nude mice injected with colon cancer cell lines that lacked fucosylation. RESULTS: Fuc-Hpt levels were significantly associated with overall and relapse-free survival, distant metastasis, clinical stage, and curability. Multivariate analysis revealed that distant metastasis was an independent factor for increased Fuc-Hpt levels. The combination of Fuc-Hpt and CEA might be a better serologic marker to predict prognosis. Fuc-Hpt levels were higher in mice with direct injection of tumor cells into the spleen than in those injected subcutaneously. CONCLUSIONS: Fuc-Hpt might be a useful marker for the prognosis of CRC. Fuc-Hpt could be produced by the tissue surrounding tumor cells, which might be the mechanism underlying Fuc-Hpt elevation associated with distant metastasis.
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Authors | Yuri Takeda, Shinichiro Shinzaki, Kumiko Okudo, Kenta Moriwaki, Kohei Murata, Eiji Miyoshi |
Journal | Cancer
(Cancer)
Vol. 118
Issue 12
Pg. 3036-43
(Jun 15 2012)
ISSN: 1097-0142 [Electronic] United States |
PMID | 22006099
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 American Cancer Society. |
Chemical References |
- Biomarkers, Tumor
- Haptoglobins
- Fucose
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Topics |
- Aged
- Animals
- Biomarkers, Tumor
(analysis)
- Colorectal Neoplasms
(blood)
- Female
- Fucose
(metabolism)
- Haptoglobins
(analysis, metabolism)
- Humans
- Male
- Mice
- Mice, Nude
- Middle Aged
- Neoplasm Transplantation
- Prognosis
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