Abstract | BACKGROUND: We assessed the 3-year clinical outcome in our single-center cohort of mainly unselected patients treated with the endothelial progenitor cell capturing stent (ECS). The ECS is coated with CD34+ antibodies specifically targeting the circulating endothelial progenitor cells population to accelerate endothelialization that in turn may prevent the occurrence of in- stent restenosis and stent thrombosis (ST). METHODS: All patients in our study had coronary artery lesions that were treated with an ECS. The majority of patients had complex lesions with an estimated high risk of restenosis. RESULTS: A total of 405 patients were enrolled. The primary end-point of target lesion failure (TLF) was defined as the composite of cardiac death, myocardial infarction, and target lesion revascularization (TLR). At 3 years, TLF was 18.3% and TLR was 14.2%. Early ST occurred in 2 patients. No cases of late and very late definite ST were reported. CONCLUSIONS: This single-center study demonstrates the safety at 3 years of the ECS in an unselected patient population, including a fair number of patients with complex lesions, reflecting daily practice. Our data compare well with drug-eluting stent and bare metal stent registries enrolling unselected patient populations. Importantly, in our analysis, no cases of late or very late definite ST were reported.
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Authors | Margo Klomp, Marcel A M Beijk, Peter Damman, Pier Woudstra, Karel T Koch, Jan G P Tijssen, Robbert J de Winter |
Journal | Journal of interventional cardiology
(J Interv Cardiol)
Vol. 24
Issue 5
Pg. 442-9
(Oct 2011)
ISSN: 1540-8183 [Electronic] United States |
PMID | 22004602
(Publication Type: Journal Article)
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Copyright | ©2011, Wiley Periodicals, Inc. |
Chemical References |
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Topics |
- Antigens, CD34
(immunology)
- Coronary Angiography
- Coronary Restenosis
(prevention & control)
- Endothelial Cells
(cytology)
- Endothelium, Vascular
(cytology)
- Female
- Humans
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Prospective Studies
- Risk Factors
- Stem Cells
(cytology)
- Stents
- Time Factors
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