The sFlt-1/PlGF ratio in different types of hypertensive pregnancy disorders and its prognostic potential in preeclamptic patients.

Abstract

OBJECTIVE:

The soluble fms-like tyrosine kinase (sFlt-1)/placental growth factor (PlGF) ratio is a reliable tool in the assessment of preeclampsia. We tested the hypothesis that the sFlt-1/PlGF ratio is able to identify women at risk for imminent delivery. We characterized the sFlt-1/PlGF ratio in different types of hypertensive pregnancy disorders.

STUDY DESIGN:

We investigated 388 singleton pregnancies with normal pregnancy outcome, 164 with PE, 36 with gestational hypertension, and 42 with chronic hypertension. sFlt-1 and PlGF were measured in serum samples.

RESULTS:

Patients with preeclampsia had a significantly increased sFlt-1/PlGF ratio as compared with controls and with patients with chronic and gestational hypertension in <34 weeks and ≥34 weeks (P < .001). Time to delivery was significantly reduced in women with preeclampsia in the highest quartile of the sFlt-1/PlGF ratio (P < .001).

CONCLUSION:

The sFlt-1/PlGF ratio allows the identification of women at risk for imminent delivery and is a reliable tool to discriminate between different types of pregnancy-related hypertensive disorders.

• Authors: Stefan Verlohren, Ignacio Herraiz, Olav Lapaire, Dietmar Schlembach, Manfred Moertl, Harald Zeisler, Pavel Calda, Wolfgang Holzgreve, Alberto Galindo, Theresa Engels, Barbara Denk, Holger Stepan
• Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 206 Issue 1 Pg. 58.e1-8 (Jan 2012) ISSN: 1097-6868 [Electronic] United States
• PMID: 22000672 (Publication Type: Journal Article)
• Copyright: Copyright © 2012 Mosby, Inc. All rights reserved.

Chemical References

• Biomarkers
• Membrane Proteins
• PIGF protein, human
• FLT1 protein, human
• Vascular Endothelial Growth Factor Receptor-1

Topics

• Adult
• Biomarkers (blood)
• Chronic Disease
• Female
• Humans
• Membrane Proteins (blood)
• Pre-Eclampsia (blood, diagnosis)
• Pregnancy
• Pregnancy Outcome
• Prognosis
• Vascular Endothelial Growth Factor Receptor-1 (blood)