Abstract | BACKGROUND: METHODS: Published oligonucleotide microarray data within the National Center for Biotechnology Information Gene Expression Omnibus database were analyzed to identify gene expression tightly correlated with NIS mRNA level among human breast tumors. NIS immunostaining was performed in a tissue microarray composed of 28 human breast tumors which had corresponding oligonucleotide microarray data available for each tumor such that gene expression associated with cell surface NIS protein level could be identified. RESULTS AND DISCUSSION: CONCLUSIONS: Further investigation on genes associated with cell surface NIS protein levels within each breast cancer molecular subtype may lead to novel targets for selectively increasing NIS expression/function in a subset of breast cancers patients.
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Authors | Sasha J Beyer, Xiaoli Zhang, Rafael E Jimenez, Mei-Ling T Lee, Andrea L Richardson, Kun Huang, Sissy M Jhiang |
Journal | BMC research notes
(BMC Res Notes)
Vol. 4
Pg. 397
(Oct 11 2011)
ISSN: 1756-0500 [Electronic] England |
PMID | 21989294
(Publication Type: Journal Article)
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