Increased circulating plasma lysophosphatidic acid in patients with acute coronary syndrome.

Abstract

BACKGROUND:

The platelet activator lysophosphatidic acid (LPA) has recently been identified as an ingredient in oxidized LDL and it has been isolated from atherosclerotic plaques. The lysophospholipase D activity of autotaxin produces LPA extracellularly from lysophosphatidylcholine (LPC). The present study determines whether circulating LPA is associated with acute coronary syndrome (ACS).

METHODS:

We enrolled 141 consecutive patients (age, 62.6±3.8 y; male, 69.2%) with ACS (n=38), stable angina pectoris (SAP; n=72) or angiographically normal coronary arteries (NCA; n=31). The relationships between LPA and other established biomarkers were examined. Concentrations of plasma LPA were determined using an enzymatic assay.

RESULTS:

Concentrations of LPA significantly correlated with LPC (r=0.549), autotaxin (r=0.370) and LDL-C (r=0.307) (all p<0.01). Lysophosphatidic acid concentrations were significantly higher in patients with ACS than with SAP and NCA (p<0.01), but did not significantly differ between patients with SAP and NCA. Multivariate logistic regression analyses revealed that the highest LPA tertile was independently associated with ACS (odds ratio 1.99, 95% CI: 1.18-3.39, p=0.02).

CONCLUSIONS:

The present study demonstrated that increased circulating plasma LPA concentrations are significantly associated with ACS.

• Authors: Tomotaka Dohi, Katsumi Miyauchi, Ryunosuke Ohkawa, Kazuhiro Nakamura, Tatsuya Kishimoto, Tadashi Miyazaki, Akihisa Nishino, Naohisa Nakajima, Kenji Yaginuma, Hiroshi Tamura, Takahiko Kojima, Ken Yokoyama, Takeshi Kurata, Kazunori Shimada, Yutaka Yatomi, Hiroyuki Daida
• Journal: Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 413 Issue 1-2 Pg. 207-12 (Jan 18 2012) ISSN: 1873-3492 [Electronic] Netherlands
• PMID: 21983165 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 Elsevier B.V. All rights reserved.

Chemical References

• Lysophospholipids
• lysophosphatidic acid

Topics

• Acute Coronary Syndrome (blood)
• Aged
• Cross-Sectional Studies
• Female
• Humans
• Lysophospholipids (blood)
• Male
• Middle Aged
• Prospective Studies