Identification of mutaprodenafil in a dietary supplement and its subsequent synthesis.

Abstract	We isolated a new illegal sildenafil analogue named mutaprodenafil from a dietary supplement for erectile dysfunction (ED) and proposed that it is an aildenafil derivative containing an imidazole moiety. We subsequently synthesized mutaprodenafil from a thioaildenafil and authenticated its structure.
Authors	Yosuke Demizu, Daigo Wakana, Hiroyuki Kamakura, Masaaki Kurihara, Haruhiro Okuda, Yukihiro Goda
Journal	Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 59 Issue 10 Pg. 1314-6 ( 2011) ISSN: 1347-5223 [Electronic] Japan
PMID	21963647 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Imidazoles Phosphodiesterase 5 Inhibitors Piperazines Purines Sulfones mutaprodenafil aildenafil Sildenafil Citrate
Topics	Dietary Supplements (analysis) Drug Contamination Erectile Dysfunction (drug therapy) Humans Imidazoles (analysis, chemical synthesis, chemistry, pharmacology) Male Molecular Structure Phosphodiesterase 5 Inhibitors (analysis, chemical synthesis, chemistry, pharmacology) Piperazines (chemistry) Purines (chemistry) Sildenafil Citrate Sulfones (chemistry)

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