Abstract | AIMS: METHODS AND RESULTS: Male δ- sarcoglycan null Bio TO2 hamsters were fed a standard low-fat diet (12% energy from fat), or high-fat diets (45% fat) comprised of either saturated fat or PUFA. The median survival was increased by the high saturated fat diet (P< 0.01; 278 days with standard diet and 361 days with high saturated fat)), but not with high PUFA (260 days) ( n = 30-35/group). Body mass was modestly elevated (∼10%) in both high fat groups. Subgroups evaluated after 24 weeks had similar left ventricular chamber size, function, and mass. Mitochondrial oxidative enzyme activity and the yield of interfibrillar mitochondria (IFM) were decreased to a similar extent in all TO2 groups compared with normal F1B hamsters. Ca(2+)-induced mitochondrial permeability transition pore opening was enhanced in IFM in all TO2 groups compared with F1B hamsters, but to a significantly greater extent in those fed the high PUFA diet compared with the standard or high saturated fat diet. CONCLUSION:
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Authors | Tatiana F Galvao, Bethany H Brown, Peter A Hecker, Kelly A O'Connell, Karen M O'Shea, Hani N Sabbah, Sharad Rastogi, Caroline Daneault, Christine Des Rosiers, William C Stanley |
Journal | Cardiovascular research
(Cardiovasc Res)
Vol. 93
Issue 1
Pg. 24-32
(Jan 01 2012)
ISSN: 1755-3245 [Electronic] England |
PMID | 21960686
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Dietary Fats
- Dietary Fats, Unsaturated
- Fatty Acids
- Phospholipids
- Sarcoglycans
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Topics |
- Animals
- Animals, Genetically Modified
- Cardiomyopathy, Dilated
(diet therapy, genetics, metabolism, pathology)
- Cricetinae
- Diet, High-Fat
- Dietary Fats
(administration & dosage)
- Dietary Fats, Unsaturated
(administration & dosage)
- Fatty Acids
(metabolism)
- Heart Failure
(diet therapy, genetics, metabolism, pathology)
- Male
- Mitochondria, Heart
(metabolism, pathology)
- Phospholipids
(metabolism)
- Sarcoglycans
(deficiency, genetics)
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