A new chromene isolated from Ageratum conyzoides.

Abstract

From the ethanol extract of the whole plant of Ageratum conyzoides L. (Compositae), one new chromene, 2,2-dimethylchromene 7-methoxy-6-O-beta-D-glucopyranoside, was isolated, together with thirteen known compounds, seven of which were being reported for the first time. The compounds were all characterized by MS, IR, 1D- and 2D-NMR spectroscopy. 7,3',5'-Tri-O-methyltricetin (7), precocene II (9), 3,5,7,4'-tetrahydroxyflavone (13) and 5,6,7,3',4',5'-hexamethoxyflavone (14) exhibited inhibitory activity on the P-388 cancer cell line with IC50 values of 12.8, 24.8, 3.5 and 7.8 microM respectively, while compound 9 exhibited inhibitory activity on the HT-29 cancer cell line with an IC50 value of 61 microM; the others showed no significant cytotoxic activity on the cell lines tested.

• Authors: Abiodun Humphrey Adebayo, Chang-Jiu Jig, Yu-Mei Zhang, Wen-Jun He, Guang-Zhi Zeng, Hong-Jin Han, Jun-Ju Xu, Afolabi Akintunde Akindahunsi, Ning-Hua Tana
• Journal: Natural product communications (Nat Prod Commun) Vol. 6 Issue 9 Pg. 1263-5 (Sep 2011) ISSN: 1934-578X [Print] United States
• PMID: 21941894 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Benzopyrans

Topics

• Ageratum (chemistry)
• Animals
• Antineoplastic Agents, Phytogenic (chemistry, pharmacology, therapeutic use)
• Benzopyrans (chemistry)
• Cell Line, Tumor
• Humans
• Mice
• Molecular Structure
• Neoplasms (drug therapy)