Serum brain-derived neurotrophic factor and antidepressant-naive major depression after lung cancer diagnosis.

Abstract

Previous studies have reported the existence of an association between brain-derived neurotrophic factor and major depression. However, the possible role of brain-derived neurotrophic factor in the pathophysiology of major depression after cancer diagnosis has not yet been investigated. Subjects were collected using the Lung Cancer Database project. Using the cut-off scores on the depression subscale of the Hospital Anxiety and Depression Scale (HADS-D), 81 subjects with depression (HADS-D > 10) and 81 subjects without depression (HADS-D < 5) were selected. The two groups were matched for age, sex, clinical stage and performance status. The serum brain-derived neurotrophic factor levels were measured using an enzyme-linked immunosorbent assay method. The serum brain-derived neurotrophic factor levels were not statistically different between the subjects in the depression group [29.1 (13.6) ng/ml; mean (SD)] and the non-depression group [31.4 (10.6) ng/ml] (P = 0.22). In a stratified analysis by gender, however, the mean serum brain-derived neurotrophic factor level in the depression group tended to be lower than that in the non-depression group among women (n = 24 pairs, P = 0.06). Major depression after cancer diagnosis is not associated with serum brain-derived neurotrophic factor levels.

• Authors: Makoto Kobayakawa, Masatoshi Inagaki, Maiko Fujimori, Kei Hamazaki, Tomohito Hamazaki, Tatsuo Akechi, Shoichiro Tsugane, Yutaka Nishiwaki, Koichi Goto, Kenji Hashimoto, Shigeto Yamawaki, Yosuke Uchitomi
• Journal: Japanese journal of clinical oncology (Jpn J Clin Oncol) Vol. 41 Issue 10 Pg. 1233-7 (Oct 2011) ISSN: 1465-3621 [Electronic] England
• PMID: 21926098 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Brain-Derived Neurotrophic Factor

Topics

• Aged
• Biomarkers (blood)
• Brain-Derived Neurotrophic Factor (blood)
• Case-Control Studies
• Depressive Disorder, Major (blood, diagnosis)
• Female
• Humans
• Japan
• Life Change Events
• Lung Neoplasms (pathology, psychology)
• Male
• Matched-Pair Analysis
• Sex Factors