Moisturizing advantages of desonide hydrogel in treating atopic dermatitis.

Abstract

The stratum corneum typically is compromised in patients with atopic dermatitis (AD). Beneficial AD treatments should provide moisture to the skin as well as restore impaired barrier function. Traditional treatments involve ointments or creams. A clinical study was conducted to determine if desonide in a hydrogel vehicle (HGV) could improve the moisture content and barrier function of the stratum corneum in adults with mild to moderate AD. Participants applied desonide hydrogel 0.05% twice daily for 4 weeks to areas of both lesional and nonlesional skin. Corneometry and transepidermal water loss (TEWL) were measured at baseline and weeks 1, 2, and 4. Statistically significant improvements in corneometry and TEWL measurements on lesional skin were observed at all study visits compared with baseline (all P < or = .002 and P < or = .04, respectively).

• Authors: Nathan S Trookman, Ronald L Rizer, Elizabeth T Ho, Rosanne O Ford, Vincent Gotz
• Journal: Cutis (Cutis) Vol. 88 Issue 1 Suppl Pg. 7-12 (Jul 2011) ISSN: 0011-4162 [Print] United States
• PMID: 21916151 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents
• Hydrogels
• Desonide

Topics

• Administration, Cutaneous
• Adult
• Anti-Inflammatory Agents (administration & dosage, therapeutic use)
• Dermatitis, Atopic (drug therapy, pathology)
• Desonide (administration & dosage, therapeutic use)
• Female
• Humans
• Hydrogels
• Male
• Middle Aged
• Severity of Illness Index
• Skin (drug effects, pathology)
• Treatment Outcome
• Water Loss, Insensible
• Young Adult