Abstract | BACKGROUND/PURPOSE: METHODS: RESULTS: The status of hENT1 expression (positive in 39 and negative in 16) was significantly associated with "clinical efficacy" (defined as more than 50% reduction of the serum carbohydrate antigen [CA] 19-9 level with stable disease [SD] or partial response [PR] according to the Response Evaluation Criteria in Solid Tumors [RECIST]) for Gem-CRT. The 1- and 3-year overall survival (OS) rates were significantly higher in the positive hENT1 expression group (82.9, 39.5%) than in the negative expression group (42.9, 14.3%) (p = 0.0037). According to combination analysis of hENT1 and TS expressions, the 1- and 3-year OS rates were significantly higher in the positive-low combination (89.1, 51.0%) group than in the negative-high group (66.7, 0%) (p = 0.023). Multivariate analysis revealed that positive hENT1 expression and R0 resection were significant prognostic factors for OS. CONCLUSIONS:
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Authors | Yasuhiro Murata, Takashi Hamada, Masashi Kishiwada, Ichiro Ohsawa, Shugo Mizuno, Masanobu Usui, Hiroyuki Sakurai, Masami Tabata, Noriko Ii, Hiroyuki Inoue, Taizo Shiraishi, Shuji Isaji |
Journal | Journal of hepato-biliary-pancreatic sciences
(J Hepatobiliary Pancreat Sci)
Vol. 19
Issue 4
Pg. 413-25
(Jul 2012)
ISSN: 1868-6982 [Electronic] Japan |
PMID | 21898089
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- CA-19-9 Antigen
- Equilibrative Nucleoside Transporter 1
- SLC29A1 protein, human
- Dihydrouracil Dehydrogenase (NADP)
- Thymidylate Synthase
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Topics |
- Adenocarcinoma
(metabolism, mortality, pathology, surgery, therapy)
- Adult
- Aged
- Aged, 80 and over
- Biomarkers
(analysis)
- CA-19-9 Antigen
(blood)
- Chemoradiotherapy, Adjuvant
- Dihydrouracil Dehydrogenase (NADP)
(metabolism)
- Equilibrative Nucleoside Transporter 1
(metabolism)
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Multivariate Analysis
- Neoadjuvant Therapy
- Neoplasm Staging
- Nutrition Assessment
- Pancreatic Neoplasms
(metabolism, mortality, pathology, surgery, therapy)
- Prognosis
- Survival Analysis
- Thymidylate Synthase
(metabolism)
- Treatment Outcome
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