[Neonatal intoxication with pyrimethamine: risk due to the absence of pediatric formulation?].

Abstract

Curative treatment of congenital toxoplasmosis is based on the association of pyrimethamine and sulfonamide. There is currently no pediatric galenic formulation. We report the case of a newborn child affected by asymptomatic congenital toxoplasmosis who received an overdose of pyrimethamine. The patient received a dose of pyrimethamine 4 times, equal to 100 times the recommended dose, due to an error in the prescription. He had partial seizures 48 h after the last medicinal absorption. We noted a lack of appetite and vomiting, with a favorable progression in 5 days. Blood analysis showed isolated, spontaneously regressive moderate cholestasis. We propose a pharmacological clarification on the treatment of congenital toxoplasmosis.

• Authors: M Genuini, C Freihuber, I Girard, I de Montgolfier, F Kieffer, D Mitanchez
• Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie (Arch Pediatr) Vol. 18 Issue 10 Pg. 1084-6 (Oct 2011) ISSN: 1769-664X [Electronic] France
• Vernacular Title: Intoxication néonatale à la pyriméthamine : un risque lié à l'absence de forme galénique pédiatrique ?
• PMID: 21885264 (Publication Type: Case Reports, English Abstract, Journal Article)
• Copyright: Copyright © 2011 Elsevier Masson SAS. All rights reserved.

Chemical References

• Antiprotozoal Agents
• Pyrimethamine

Topics

• Antiprotozoal Agents (administration & dosage, adverse effects)
• Drug Overdose
• Humans
• Infant, Newborn
• Medication Errors (adverse effects)
• Prognosis
• Pyrimethamine (administration & dosage, adverse effects)
• Seizures (chemically induced)
• Toxoplasmosis, Congenital (drug therapy)