Apoptosis of HL-60 leukemia cells induced by carbazole alkaloids isolated from Murraya euchrestifolia.

Abstract

We carried out primary screening of 13 carbazole alkaloids isolated from the plant species Murraya euchrestifolia (Rutaceae) on cell growth inhibition of the human leukemia cell line HL-60. Among them, murrayafoline-A (1) and murrayazolinine (7) exhibited significant growth suppression due to apoptosis mediated by the activation of the caspase-9/caspase-3 pathway.

• Authors: Chihiro Ito, Masataka Itoigawa, Keisuke Nakao, Tomiyasu Murata, Norio Kaneda, Hiroshi Furukawa
• Journal: Journal of natural medicines (J Nat Med) Vol. 66 Issue 2 Pg. 357-61 (Apr 2012) ISSN: 1861-0293 [Electronic] Japan
• PMID: 21879331 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alkaloids
• Antineoplastic Agents, Phytogenic
• Carbazoles
• Plant Extracts
• carbazole
• Caspase 3
• Caspase 9

Topics

• Alkaloids (chemistry, pharmacology)
• Antineoplastic Agents, Phytogenic (chemistry, pharmacology)
• Apoptosis (drug effects)
• Carbazoles (chemistry, pharmacology)
• Caspase 3 (metabolism)
• Caspase 9 (metabolism)
• HL-60 Cells
• Humans
• Molecular Structure
• Murraya (chemistry)
• Plant Extracts (chemistry, pharmacology)