Abstract | PURPOSE: To determine the local recurrence rate and factors associated with recurrence after intraoperative ablation of colorectal cancer liver metastases. METHODS: A retrospective analysis of a prospectively maintained database was performed for patients who underwent ablation of a hepatic colorectal cancer metastasis in the operating room from April 1996 to March 2010. Kaplan-Meier survival curves and Cox models were used to determine recurrence rates and assess significance. RESULTS: Ablation was performed in 10% (n = 158 patients) of all cases during the study period. Seventy-eight percent were performed in conjunction with a liver resection. Of the 315 tumors ablated, most tumors were ≤ 1 cm in maximum diameter (53%). Radiofrequency ablation was used to treat most of the tumors (70%). Thirty-six tumors (11%) had local recurrence as part of their recurrence pattern. Disease recurred in the liver or systemically after 212 tumors (67%) were ablated. On univariate analysis, tumor size greater than 1 cm was associated with a significantly increased risk of local recurrence (hazard ratio 2.3, 95% confidence interval 1.2-4.5, P = 0.013). The 2 year ablation zone recurrence-free survival was 92% for tumors ≤ 1 cm compared to 81% for tumors >1 cm. On multivariate analysis, tumor size of >1 cm, lack of postoperative chemotherapy, and use of cryotherapy were significantly associated with a higher local recurrence rate. CONCLUSIONS: Intraoperative ablation appears to be highly effective treatment for hepatic colorectal tumors ≤ 1 cm.
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Authors | T Peter Kingham, Michael Tanoue, Anne Eaton, Flavio G Rocha, Richard Do, Peter Allen, Ronald P De Matteo, Michael D'Angelica, Yuman Fong, William R Jarnagin |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 19
Issue 3
Pg. 834-41
(Mar 2012)
ISSN: 1534-4681 [Electronic] United States |
PMID | 21879262
(Publication Type: Journal Article)
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Catheter Ablation
- Chemoradiotherapy, Adjuvant
- Colorectal Neoplasms
(pathology)
- Female
- Hepatectomy
- Humans
- Liver Neoplasms
(mortality, secondary, surgery)
- Male
- Middle Aged
- Neoadjuvant Therapy
- Neoplasm Recurrence, Local
- Survival Rate
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