[Postoperative analgesia of continuous intravenous fentanyl or dexmedetomidine for patients receiving anticoagulant therapy].

Abstract

BACKGROUND:

It is difficult to achieve good postoperative analgesia in patients who undergo abdominal aortic surgery without epidural analgesia and who have a bleeding tendency or are undergoing anticoagulation therapy. Intravenous fentanyl analgesia can be used in such patients, but it occasionally causes respiratory depression. Dexmedetomidine is used to achieve postoperative sedation and analgesia without respiratory depression. We compared the methods used to achieve postoperative analgesia after abdominal aortic surgery.

METHODS:

In the intravenous fentanyl analgesia group (group F, n = 15), 0.5 microg x kg(-1) x hr(-1) fentanyl infusion was initiated during operation and continued to the next morning. In the intravenous dexmedetomidine group (group D, n = 15), 0.4-0.7 microg x kg(-1) x hr(-1) dexmedetomidine infusion was commenced during the operation and decreased to 0.2-0.7 microg x kg(-1) x hr- in the next morning. In the control group (group C, n = 15), continuous intravenous analgesia was not used. The frequency of analgesic use, Ramsay score, PaCO2 value, and rate of nausea and shivering were evaluated on the next morning.

RESULTS:

The frequency of analgesic use and Ramsay score were similar in groups F and D. The Paco2 value was higher in group F than group D.

CONCLUSIONS:

With regard to respiratory depression, intravenous dexmedetomidine analgesia is safer and more useful than intravenous fentanyl analgesia.

• Authors: Yoshiko Onodera, Akio Yamagishi, Takayuki Kunisawa, Atsushi Kurosawa, Osamu Takahata, Hiroshi Iwasaki
• Journal: Masui. The Japanese journal of anesthesiology (Masui) Vol. 60 Issue 8 Pg. 936-40 (Aug 2011) ISSN: 0021-4892 [Print] Japan
• PMID: 21861419 (Publication Type: Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Analgesics, Non-Narcotic
• Analgesics, Opioid
• Anticoagulants
• Dexmedetomidine
• Fentanyl

Topics

• Aged
• Analgesics, Non-Narcotic (administration & dosage)
• Analgesics, Opioid (administration & dosage, adverse effects)
• Anesthesia, General
• Anticoagulants (adverse effects)
• Aorta, Abdominal (surgery)
• Dexmedetomidine (administration & dosage)
• Female
• Fentanyl (administration & dosage, adverse effects)
• Humans
• Infusions, Intravenous
• Male
• Middle Aged
• Pain, Postoperative (prevention & control)
• Respiratory Insufficiency (chemically induced)
• Vascular Surgical Procedures