Persistence of varicella zoster virus DNA in saliva after herpes zoster.

Abstract

Analysis of saliva samples from individuals aged ≥ 60 years who had a history of zoster (group 1), zoster and postherpetic neuralgia (PHN; group 2), or no history of zoster (group 3) revealed varicella zoster virus (VZV) DNA in saliva samples from 11 of 17 individuals in group 1, 10 of 15 individuals in group 2, and 2 of 17 individuals in group 3. The frequency of VZV DNA detection was significantly higher (P = .001) in saliva of subjects with a history of zoster, with or without PHN (21 [67%] of 32 subjects in groups 1 and 2), than in saliva of age-matched subjects with no zoster history (2 [12%] of 17 subjects in group 3). Thus, persistence of VZV DNA in saliva is the outcome of zoster, independent of PHN. Because VZV infection can produce neurological and ocular disease without zoster rash, future studies are needed to establish whether VZV DNA can be detected in the saliva of such patients.

• Authors: Maria A Nagel, Alexander Choe, Randall J Cohrs, Igor Traktinskiy, Kyle Sorensen, Satish K Mehta, Duane L Pierson, Stephen K Tyring, Kassie Haitz, Catherine Digiorgio, Whitney Lapolla, Don Gilden
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 204 Issue 6 Pg. 820-4 (Sep 15 2011) ISSN: 1537-6613 [Electronic] United States
• PMID: 21849278 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S., Comment)

Chemical References

• DNA, Viral

Topics

• DNA, Viral (isolation & purification)
• Herpes Zoster (complications, virology)
• Humans
• Neuralgia, Postherpetic (virology)
• Saliva (virology)
• Varicellovirus (isolation & purification)