Coexistence of Hashimoto's thyroiditis with papillary thyroid carcinoma: the influence of lymph node metastasis.

Abstract

BACKGROUND:

The aim of this study was to evaluate the influence of coexistent Hashimoto's thyroiditis with papillary thyroid carcinoma on lymph node metastasis.

METHODS:

The coexistent Hashimoto's thyroiditis group was defined by the presence of thyroid autoantibodies or pathologic confirmation. The control group did not have autoantibodies, disease, or ultrasound findings of Hashimoto's thyroiditis.

RESULTS:

For the Hashimoto's thyroiditis group, only central lymph node metastasis had a lower frequency and the mean number of central metastatic lymph nodes was lower than in the control group after adjustment. With regard to lateral lymph node involvement, there was no significant difference between the 2 groups. The multivariate analysis showed a negative association between the coexistence of Hashimoto's thyroiditis and central lymph node metastasis.

CONCLUSIONS:

Coexisting Hashimoto's thyroiditis in patients with papillary thyroid carcinoma was identified as a negative independent predictive factor for central lymph node metastasis.

• Authors: Sang Soo Kim, Byung Joo Lee, Jin Choon Lee, Seong-Jang Kim, Yun Kyung Jeon, Mi Ra Kim, Jeong Eun Huh, Ji Young Mok, Bo Hyun Kim, Yong Ki Kim, In Joo Kim
• Journal: Head & neck (Head Neck) Vol. 33 Issue 9 Pg. 1272-7 (Sep 2011) ISSN: 1097-0347 [Electronic] United States
• PMID: 21837696 (Publication Type: Journal Article)
• Copyright: Copyright © 2010 Wiley Periodicals, Inc.

Topics

• Adolescent
• Adult
• Aged
• Carcinoma, Papillary (complications, pathology)
• Case-Control Studies
• Female
• Hashimoto Disease (complications)
• Humans
• Lymph Node Excision
• Lymphatic Metastasis
• Male
• Middle Aged
• Multivariate Analysis
• Prognosis
• Thyroid Neoplasms (complications, pathology)
• Young Adult