Abstract | BACKGROUND: METHODS: A total of 96 patients with adenocarcinoma of the colon or rectum (n = 84), or stomach (n = 12) who had developed oxaliplatin-induced painful neuropathy were enrolled. Ultracet was administered at 1 tablet every 6 hours, and pain was assessed and scored using a visual analog scale (VAS). The OPRM1 A118G polymorphism was examined with a polymerase chain reaction-direct sequencing method. RESULTS: The allelic frequency of variant (118G) allele was 39.6%, and the prevalence of OPRM1-118 AA, AG, and GG genotypes was 31.3% ( n = 30), 58.3% (n = 56), and 10.4% (n = 10), respectively. For all patients, the mean pre-treatment and post-treatment VAS scores were 3.1 and 2.1, respectively (P < .001). Patients with AA genotype had a better analgesic effect than those with G allele variants (AG or GG genotypes). Pre-treatment and post-treatment VAS scores for patients with G allele variants were 3.1 and 2.6, respectively; however, for patients with AA genotype, pre-treatment and post-treatment VAS scores were 3.0 and 0.9, respectively (P < .001). The requirement for rescue analgesia was also higher for patients with G allele variants (P = .01). CONCLUSIONS:
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Authors | Yu-Chang Liu, Wei-Shu Wang |
Journal | Cancer
(Cancer)
Vol. 118
Issue 6
Pg. 1718-25
(Mar 15 2012)
ISSN: 1097-0142 [Electronic] United States |
PMID | 21837673
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 American Cancer Society. |
Chemical References |
- Analgesics
- Antineoplastic Agents
- Drug Combinations
- OPRM1 protein, human
- Organoplatinum Compounds
- Receptors, Opioid, mu
- Ultracet
- Oxaliplatin
- Acetaminophen
- Tramadol
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Topics |
- Acetaminophen
(therapeutic use)
- Adult
- Aged
- Analgesics
(therapeutic use)
- Antineoplastic Agents
(adverse effects)
- Drug Combinations
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Organoplatinum Compounds
(adverse effects)
- Oxaliplatin
- Peripheral Nervous System Diseases
(chemically induced, drug therapy)
- Polymorphism, Genetic
- Receptors, Opioid, mu
(genetics)
- Tramadol
(therapeutic use)
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