Abstract | PURPOSE: METHODS: Thirty-four patients with acute central serous chorioretinopathy were randomly assigned to receive photodynamic therapy with half-dose verteporfin (n = 24) or placebo (n = 10). Multifocal electroretinography was performed at baseline and at 12 months, and serial changes in response amplitudes were expressed as amplitude ratios. The mfERG amplitude ratios, best-corrected visual acuity, and optical coherence tomography central foveal thickness were compared between the verteporfin and placebo groups. Correlation analysis between the mfERG response amplitude ratios and the best-corrected visual acuity changes and reduction in optical coherence tomography central foveal thickness were also performed. RESULTS: At 12 months, the mean visual improvement was 1.8 line and 0.1 line for the verteporfin and placebo groups, respectively (P = 0.003). Eyes in the verteporfin group had significantly lower central foveal thickness (P = 0.028) and higher P1 mfERG response ratios for Rings 1 and 2 at 12 months compared with the eyes in the placebo group (P = 0.030 and P = 0.018, respectively). Significant correlations between mfERG N1 and P1 amplitude ratios at the central rings were observed with both changes in best-corrected visual acuity and reductions in optical coherence tomography central foveal thickness (P < 0.05). CONCLUSIONS:
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Authors | Zenith H Y Wu, Ricky Y K Lai, Yolanda W Y Yip, Wai Man Chan, Dennis S C Lam, Timothy Y Y Lai |
Journal | Retina (Philadelphia, Pa.)
(Retina)
2011 Jul-Aug
Vol. 31
Issue 7
Pg. 1378-86
ISSN: 1539-2864 [Electronic] United States |
PMID | 21836413
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Photosensitizing Agents
- Porphyrins
- Verteporfin
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Topics |
- Acute Disease
- Adult
- Central Serous Chorioretinopathy
(drug therapy, physiopathology)
- Electroretinography
- Female
- Humans
- Male
- Photochemotherapy
- Photosensitizing Agents
(administration & dosage)
- Porphyrins
(administration & dosage)
- Retina
(physiopathology)
- Tomography, Optical Coherence
- Verteporfin
- Visual Acuity
(physiology)
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