RNA-binding proteins may regulate every aspect of
RNA metabolism, including
pre-mRNA splicing,
mRNA trafficking, stability and translation of many genes. The dynamic association of these
proteins with
RNA defines the lifetime, cellular localization, processing and the rate at which a specific
mRNA is translated. One of the pathways involved in regulating of mRNA stability is mediated by adenylate uridylate-rich
element (ARE)
binding proteins. These
proteins are involved in processes of apoptosis,
tumorigenesis and development. Out of many ARE-
binding proteins, two of them AUF1 and HuR were studied most extensively and reported to regulate the mRNA stability in vivo. Our previously published data demonstrate that both
proteins are involved in thyroid
carcinogenesis. Several other reports postulate that
mRNA binding proteins may participate in
thyroid hormone actions. However, until now, exacts mechanisms and the possible role of post-transcriptional regulation and especially the role of AUF1 and HuR in those processes remain not fully understood. In this study we shortly review the possible function of both
proteins in relation to development and various physiological and pathophysiological processes, including thyroid function and disorders.