Anti-angiogenic activity evaluation of secondary metabolites from Calycolpus moritzianus leaves.

Abstract

Angiogenesis is a crucial step in many pathological conditions like cancer, inflammation and metastasis formation; on these basis the search for antiangiogenic agents has widened. In order to identify new compounds able to interfere in the Vascular Endothelial Growth Factor Receptor-1 (VEGFR-1, also known as Flt-1) recognition by VEGFs family members, we screened Calycolpus moritzianus (O. Berg) Burret leaves extracts by a competitive ELISA-based assay. MeOH and CHCl3 extracts and several their fractions demonstrated to be able to prevent VEGF or PlGF interaction with Flt-1, with an inhibition about 50% at concentration of 100 microg/mL. Phytochemical and pharmacological investigation of the active fractions led to the isolation of flavonoids, and terpenes.

• Authors: Laura Lepore, Maria J Gualtieri, Nicola Malafronte, Roberta Cotugno, Fabrizio Dal Piaz, Letizia Ambrosio, Sandro De Falco, Nunziatina De Tommasi
• Journal: Natural product communications (Nat Prod Commun) Vol. 6 Issue 7 Pg. 943-6 (Jul 2011) ISSN: 1934-578X [Print] United States
• PMID: 21834229 (Publication Type: Journal Article)

Chemical References

• Angiogenesis Inhibitors
• Flavonoids
• Pregnancy Proteins
• Terpenes
• Vascular Endothelial Growth Factor A
• Placenta Growth Factor

Topics

• Angiogenesis Inhibitors (chemistry, isolation & purification, pharmacology)
• Enzyme-Linked Immunosorbent Assay
• Flavonoids (chemistry, isolation & purification, pharmacology)
• Myrtaceae (chemistry, metabolism)
• Placenta Growth Factor
• Plant Leaves (chemistry, metabolism)
• Pregnancy Proteins (antagonists & inhibitors)
• Terpenes (chemistry, isolation & purification, pharmacology)
• Vascular Endothelial Growth Factor A (antagonists & inhibitors)