Abstract |
Cadmium (Cd) is a toxic metal and can induce and/or promote diseases in humans ( cancer, aging diseases, kidney and bone diseases, etc.). Its toxicity involves many mechanisms including the alteration of copper (Cu) and zinc (Zn) homeostasis leading to reactive oxygen species (ROS) production, either directly or through the inhibition of antioxidant activities. Importantly, ROS can induce oxidative damages in cells. Cadmium, Cu and Zn are also able to induce glutathione (GSH) and metallothioneins (MT) synthesis in a cell-type-dependent manner. As a consequence, the effects induced by these three metals result simultaneously from the inhibition of antioxidant activities and the induction of other factors such as GSH and MT synthesis. MT levels are regulated not only by the p53 protein in a cell-type-dependent manner, or by transcription factors such as metal-responsive transcription factor 1 (MTF-1) and cellular Zn levels but also by cellular GSH level. As described in the literature, DNA damage, GSH and MT levels are sensitive biomarkers used to identify Cd-induced toxicity alone or together with Cu and Zn homeostasis alteration.
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Authors | Yves Nzengue, Serge M Candéias, Sylvie Sauvaigo, Thierry Douki, Alain Favier, Walid Rachidi, Pascale Guiraud |
Journal | Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
(J Trace Elem Med Biol)
Vol. 25
Issue 3
Pg. 171-80
(Jul 2011)
ISSN: 1878-3252 [Electronic] Germany |
PMID | 21820296
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2011 Elsevier GmbH. All rights reserved. |
Chemical References |
- Biomarkers
- Cadmium
- Copper
- Zinc
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Topics |
- Animals
- Biomarkers
(metabolism)
- Cadmium
(toxicity)
- Copper
(toxicity)
- Homeostasis
(drug effects)
- Humans
- Oxidation-Reduction
(drug effects)
- Zinc
(toxicity)
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