A pH-responsive mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance.

Abstract

A type of pH-responsive nano multi-drug delivery systems (nano-MDDSs) with uniform particle size (100 ± 13 nm) and excellent monodispersity was developed by in situ co-self-assembly among water-insoluble anti-cancer drug (doxorubicin, DOX), surfactant micelles (CTAB) as chemosensitiver and silicon species forming drugs/surfactant micelles-co-loaded mesoporous silica nanoparticles (drugs@micelles@MSNs or DOX@CTAB@MSNs) via a micelles-MSNs self-assembly mechanism. The nano-MDDS DOX@CTAB@MSNs had a highly precise pH-responsive drug release behavior both in vitro and in vivo, and exhibited high drug efficiencies against drug-resistant MCF-7/ADR cells as well as drug-sensitive MCF-7 cells by the MSNs-mediated transmembrane delivery, the sustained drug release and the high anti-cancer and multi-drug resistance (MDR)-overcoming efficiencies. The MDR-overcoming mechanism was proved to be a synergistic cell cycle arrest/apoptosis-inducing effect resulted from the chemosensitization of the surfactant CTAB. These results demonstrated a very promising nano-MDDS for the pH-responsive controlled drug release and the cancer MDR overcoming.

• Authors: Qianjun He, Yu Gao, Lingxia Zhang, Zhiwen Zhang, Fang Gao, Xiufeng Ji, Yaping Li, Jianlin Shi
• Journal: Biomaterials (Biomaterials) Vol. 32 Issue 30 Pg. 7711-20 (Oct 2011) ISSN: 1878-5905 [Electronic] Netherlands
• PMID: 21816467 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Ltd. All rights reserved.

Chemical References

• Antibiotics, Antineoplastic
• Delayed-Action Preparations
• Micelles
• Surface-Active Agents
• Silicon Dioxide
• Doxorubicin

Topics

• Animals
• Antibiotics, Antineoplastic (administration & dosage, pharmacology)
• Cell Line, Tumor
• Delayed-Action Preparations (chemistry)
• Doxorubicin (administration & dosage, pharmacology)
• Drug Resistance, Multiple (drug effects)
• Drug Resistance, Neoplasm (drug effects)
• Humans
• Hydrogen-Ion Concentration
• Mice
• Mice, Nude
• Micelles
• Nanoparticles (chemistry)
• Neoplasms (drug therapy)
• Silicon Dioxide (chemistry)
• Surface-Active Agents (chemistry)