Chlamydia trachomatis and Mycoplasma genitalium plasma antibodies in relation to epithelial ovarian tumors.

Abstract

OBJECTIVE:

To assess associations of Chlamydia trachomatis and Mycoplasma genitalium antibodies with epithelial ovarian tumors.

METHODS:

Plasma samples from 291 women, undergoing surgery due to suspected ovarian pathology, were analyzed with respect to C. trachomatis IgG and IgA, chlamydial Heat Shock Protein 60-1 (cHSP60-1) IgG and M. genitalium IgG antibodies. Women with borderline tumors (n=12), ovarian carcinoma (n=45), or other pelvic malignancies (n=11) were matched to four healthy controls each.

RESULTS:

Overall, there were no associations of antibodies with EOC. However, chlamydial HSP60-1 IgG antibodies were associated with type II ovarian cancer (P=.002) in women with plasma samples obtained >1 year prior to diagnosis (n=7). M. genitalium IgG antibodies were associated with borderline ovarian tumors (P=.01).

CONCLUSION:

Chlamydial HSP60-1 IgG and M. genitalium IgG antibodies are in this study associated with epithelial ovarian tumors in some subsets, which support the hypothesis linking upper-genital tract infections and ovarian tumor development.

• Authors: Annika Idahl, Eva Lundin, Margaretha Jurstrand, Urban Kumlin, Fredrik Elgh, Nina Ohlson, Ulrika Ottander
• Journal: Infectious diseases in obstetrics and gynecology (Infect Dis Obstet Gynecol) Vol. 2011 Pg. 824627 ( 2011) ISSN: 1098-0997 [Electronic] Egypt
• PMID: 21811380 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Bacterial
• Chaperonin 60
• Immunoglobulin G

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Antibodies, Bacterial (blood)
• Carcinoma, Ovarian Epithelial
• Case-Control Studies
• Chaperonin 60 (blood)
• Chlamydia Infections (immunology)
• Chlamydia trachomatis (immunology)
• Female
• Humans
• Immunoglobulin G (blood)
• Middle Aged
• Mycoplasma Infections (immunology)
• Mycoplasma genitalium (immunology)
• Neoplasms, Glandular and Epithelial (immunology, microbiology, surgery)
• Ovarian Neoplasms (immunology, microbiology, surgery)