Abstract | OBJECTIVE: MATERIALS AND METHODS: A total of 112 patients (120 lesions) with stable angina who underwent PCI under intravascular ultrasound guidance, and who underwent follow-up coronary angiography about 8 months after PCI from August 2004 to December 2009 were enrolled in this study. RESULTS: Plasma adiponectin levels were significantly lower in the group with restenosis (n=13) than in the group without restenosis (n=107) (4.2±1.5 vs. 6.8±4.9 μg/ml, P<0.0001). A two-graph receiver operating characteristic curve analysis indicated that the cut-off point of adiponectin was 6.0 μg/ml. Although plasma adiponectin levels were independent of well-known risk factors of CAD, a multivariate logistic regression analysis indicated that the higher adiponectin group (patients with hyperadiponectinemia) was independently associated with lower risk of restenosis (odds ratio=0.21, 95% confidence interval=0.03-0.82). CONCLUSION: Hyperadiponectinemia (plasma adiponectin levels ≥6.0 μg/ml) is independently associated with a lower risk of restenosis. Thus, the plasma adiponectin level may be useful as a marker of restenosis independent of preinterventional intravascular ultrasound variables.
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Authors | Takahiro Mito, Shin-Ichiro Miura, Atsushi Iwata, Joji Morii, Makoto Sugihara, Amane Ike, Ken Mori, Akira Kawamura, Hiroaki Nishikawa, Bo Zhang, Keijiro Saku |
Journal | Coronary artery disease
(Coron Artery Dis)
Vol. 22
Issue 7
Pg. 451-7
(Nov 2011)
ISSN: 1473-5830 [Electronic] England |
PMID | 21811155
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- ADIPOQ protein, human
- Adiponectin
- Biomarkers
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Topics |
- Adiponectin
(blood)
- Aged
- Angina, Stable
(blood, diagnostic imaging, therapy)
- Angioplasty, Balloon, Coronary
(adverse effects)
- Biomarkers
(blood)
- Chi-Square Distribution
- Coronary Angiography
- Coronary Restenosis
(blood, diagnostic imaging, etiology)
- Female
- Humans
- Japan
- Logistic Models
- Male
- Middle Aged
- Odds Ratio
- Predictive Value of Tests
- ROC Curve
- Retrospective Studies
- Risk Assessment
- Risk Factors
- Time Factors
- Treatment Outcome
- Ultrasonography, Interventional
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