The correlation between lipids ratio and degree of coronary artery stenosis.

Abstract

OBJECTIVE:

The aim of the study was to explore the relationship between lipids ratio and the degree of coronary artery stenosis.

METHODS:

According to the Gensini score of inpatients in the Cardiology Department of the Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China, from January 2008 to June 2010, a total of 207 patients (group 1: control group = 34 patients; group 2: 1-30 score group = 84 patients; group 3: 31-90 score group = 66 patients; and group 4: >90 score group = 23 patients) were enrolled, and the relationship between lipids and the degree of coronary artery stenosis was determined.

RESULTS:

Our study showed that the severity of coronary lesions was increased with the elevation of low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), LDL-C, triglycerides (TG), TC/HDL-C, TG/HDL-C and reduction of HDL-C. Compared with group 1, LDL-C/HDL-C, TC/HDL-C were significantly increased in groups 2, 3 and 4 (p < 0.05), and compared with group 2, LDL-C/HDL-C, TC/HDL-C in groups 3 and 4 were significantly increased (p < 0.05). There were no differences in the value of TG, TG/HDL-C among groups 2, 3 and 4 (p > 0.05). Furthermore, the Pearson correlation analysis revealed that LDL-C/HDL-C (r = 0.54, p < 0.05) and TC/HDL-C (r = 0.50, p < 0.05) were significantly and positively correlated with the coronary artery lesions.

CONCLUSIONS:

The results suggested that the severity of coronary artery lesions were correlated with abnormal lipid metabolism, and LDL-C/HDL-C, TC/HDL-C are better indicators than other measures. However, the predictive value of TG/HDL-C needs further study. Received for publication 25 October 2010; accepted for publication 14 April 2011.

• Authors: Dan Yang, Xianbao Liu, Meixiang Xiang
• Journal: High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension (High Blood Press Cardiovasc Prev) Vol. 18 Issue 2 Pg. 53-6 (Jun 01 2011) ISSN: 1179-1985 [Electronic] New Zealand
• PMID: 21806079 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Lipids

Topics

• Aged
• Analysis of Variance
• Biomarkers (blood)
• Case-Control Studies
• Chi-Square Distribution
• China
• Coronary Angiography
• Coronary Stenosis (blood, diagnostic imaging)
• Female
• Humans
• Lipids (blood)
• Male
• Middle Aged
• Predictive Value of Tests
• Severity of Illness Index