Synthesis and biological evaluation of two salidroside analogues in the PC12 cell model exposed to hypoglycemia and serum limitation.

Abstract

Salidroside is a phenylpropanoid glycoside isolated from Rhodiola rosea L., a traditional Chinese medicinal plant, and has displayed a broad spectrum of pharmacological properties. In this paper, two analogues were prepared with the glucosamine and N-acetylglucosamine as glycosyl donor, 2-(4-hydroxyphenyl)ethanol as glycosyl acceptor. The effects of them over PC12 cell model exposed to hypoglycemia and serum limitation were assessed with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, Flow Cytometry and Western blot analysis.

• Authors: Yibing Guo, Xiaohong Li, Yahong Zhao, Yongxing Si, Hui Zhu, Yumin Yang
• Journal: Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 59 Issue 8 Pg. 1045-7 ( 2011) ISSN: 1347-5223 [Electronic] Japan
• PMID: 21804252 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Glucosides
• Phenols
• rhodioloside

Topics

• Animals
• Apoptosis (drug effects)
• Glucosides (chemical synthesis, chemistry, pharmacology)
• Hypoglycemia (metabolism)
• PC12 Cells
• Phenols (chemical synthesis, chemistry, pharmacology)
• Rats
• Rhodiola (chemistry)
• Serum (metabolism)