Abstract | INTRODUCTION: AIM: The aim of our study was to evaluate for the presence of ox-LDL in the peritoneal fluid (PF) of women with and without endometriosis. MATERIAL AND METHODS: A total of 60 women who underwent laparoscopy were divided into groups: endometriosis sufferers with minimal to mild (n 20) and moderate to severe (n 20) stages, and the reference group (n 20) with functional follicle ovarian cysts. Oxidized LDL levels were determined in the PF using enzyme immunoassay RESULTS:
Oxidized LDL levels were detectable in all peritoneal fluid samples. Significantly increased levels of ox-LDL were observed in PF of women with stage III/IV endometriosis compared to the reference group (p = 0.03). However peritoneal fluid ox-LDL concentrations did not differ significantly between patients with minimal/mild and women with moderate/severe stage of the disease (p = 0.2). No significant difference in the PF ox-LDL concentrations was also found between women with stage I/II endometriosis and patients with follicle cysts (p = 0.3). CONCLUSIONS: Increased peritoneal fluid ox-LDL levels observed in women with advanced-stage endometriosis suggest the important role of oxidative stress in the pathogenesis of the disease.
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Authors | Grzegorz Polak, Diana Mazurek, Ewelina Rogala, Aldona Nowicka, Magdalena Derewianka-Polak, Jan Kotarski |
Journal | Ginekologia polska
(Ginekol Pol)
Vol. 82
Issue 3
Pg. 191-4
(Mar 2011)
ISSN: 0017-0011 [Print] Poland |
Vernacular Title | Zwiekszone stezenie utlenionego cholesterolu LDL w płynie otrzewnowym kobiet z zaawansowana endometrioza. |
PMID | 21735686
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Chemical References |
- Lipoproteins, LDL
- oxidized low density lipoprotein
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Topics |
- Adult
- Ascitic Fluid
(metabolism)
- Endometriosis
(metabolism, pathology)
- Endometrium
(metabolism)
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Lipoproteins, LDL
(analysis)
- Oxidation-Reduction
- Oxidative Stress
- Peritoneum
(metabolism)
- Poland
- Predictive Value of Tests
- Severity of Illness Index
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