Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: SUMMARY: Glycation of LDL occurs chiefly because of the nonenzymatic reaction of glucose and its metabolites with the free amino groups of lysine of which apolipoprotein B is rich. Higher concentrations of glycated LDL are present in diabetes than in nondiabetic individuals and metabolic syndrome. Even in nondiabetic individuals, however, there is generally more circulating glycated LDL than oxidatively modified LDL. Probably, oxidation and glycation of LDL are partially interdependent and indisputably coexist, and both prevent LDL receptor-mediated uptake and promote macrophage scavenger receptor-mediated LDL uptake. The recognition that LDL glycation is at least as important as oxidation in atherogenesis may lead to improvements in our understanding of its mechanism and how to prevent it.
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Authors | Handrean Soran, Paul N Durrington |
Journal | Current opinion in lipidology
(Curr Opin Lipidol)
Vol. 22
Issue 4
Pg. 254-61
(Aug 2011)
ISSN: 1473-6535 [Electronic] England |
PMID | 21734572
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Antioxidants
- Apolipoproteins
- Hypoglycemic Agents
- Lipoproteins, LDL
- oxidized low density lipoprotein
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Topics |
- Animals
- Antioxidants
(therapeutic use)
- Apolipoproteins
(blood)
- Atherosclerosis
(physiopathology)
- Clinical Trials as Topic
- Glycosylation
- Humans
- Hypoglycemic Agents
(therapeutic use)
- Lipid Metabolism
- Lipoproteins, LDL
(blood)
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