Variability in estrogen-metabolizing genes and their association with genomic instability in untreated breast cancer patients and healthy women.

Abstract

In the present study, we investigated the relationship between polymorphisms in the estrogen-metabolizing genes CYP17, CYP1B1, CYP1A1, and COMT and genomic instability in the peripheral blood lymphocytes of 62 BC patients and 62 controls considering that increased or prolonged exposure to estrogen can damage the DNA molecule and increase the genomic instability process in breast tissue. Our data demonstrated increased genomic instability in BC patients and that individuals with higher frequencies of MN exhibited higher risk to BC when belonging Val/Met genotype of the COMT gene. We also observed that CYP17 and CYP1A1 polymorphisms can modify the risk to BC depending on the menopause status. We can conclude that the genetic background in estrogen metabolism pathway can modulate chromosome damage in healthy controls and patients and thereby influence the risk to BC. These findings suggest the importance to ally biomarkers of susceptibility and effects to estimate risk groups.

• Authors: Raquel Alves dos Santos, Ana Cláudia Teixeira, Mônica Beatriz Mayorano, Hélio Humberto Angotti Carrara, Jurandyr de Andrade, Catarina Satie Takahashi
• Journal: Journal of biomedicine & biotechnology (J Biomed Biotechnol) Vol. 2011 Pg. 571784 ( 2011) ISSN: 1110-7251 [Electronic] United States
• PMID: 21716904 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Estrogens
• Aryl Hydrocarbon Hydroxylases
• CYP1B1 protein, human
• Cytochrome P-450 CYP1A1
• Cytochrome P-450 CYP1B1
• Steroid 17-alpha-Hydroxylase
• Catechol O-Methyltransferase

Topics

• Adult
• Aryl Hydrocarbon Hydroxylases (genetics)
• Breast Neoplasms (epidemiology, genetics)
• Catechol O-Methyltransferase (genetics)
• Cells, Cultured
• Cytochrome P-450 CYP1A1 (genetics)
• Cytochrome P-450 CYP1B1
• Estrogens (genetics, metabolism)
• Female
• Genomic Instability (genetics)
• Genotype
• Humans
• Middle Aged
• Polymorphism, Genetic
• Risk Factors
• Steroid 17-alpha-Hydroxylase (genetics)