Association of lipoprotein-associated phospholipase A(2) and endothelial function in the Multi-Ethnic Study of Atherosclerosis (MESA).

Abstract

Mechanisms underlying the role of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) in atherosclerotic development are not completely understood. We evaluated the relationship of Lp-PLA(2) with endothelial dysfunction, an early manifestation of atherosclerosis, in a cohort without known clinical cardiovascular disease. A total of 2809 participants in the Multi-Ethnic Study of Atherosclerosis underwent plasma Lp-PLA(2) mass and activity measurement and brachial artery flow-mediated vasodilation testing. In adjusted linear regression models, higher Lp-PLA(2) mass and activity levels were not associated with lower endothelial function (-0.04%, p = 0.51 and -0.09%, p = 0.10, respectively). Among individuals with subclinical atherosclerosis based on ankle-brachial index (ABI) or carotid intima-media thickness (IMT), Lp-PLA(2) mass and activity were not associated with lower endothelial function (-0.03%, p = 0.88 and -0.31%, p = 0.16 for ABI < 1.00; 0.01%, p = 0.94 and -0.15%, p = 0.20 for abnormal carotid IMT). In summary, Lp-PLA(2) is not associated with endothelial dysfunction, suggesting its role in atherosclerosis development is primarily related to other factors.

• Authors: Parveen K Garg, Robyn L McClelland, Nancy S Jenny, Michael Criqui, Kiang Liu, Joseph F Polak, Neal W Jorgensen, Mary Cushman
• Journal: Vascular medicine (London, England) (Vasc Med) Vol. 16 Issue 4 Pg. 247-52 (Aug 2011) ISSN: 1477-0377 [Electronic] England
• PMID: 21708876 (Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural)

Chemical References

• Biomarkers
• Phospholipases A2
• 1-Alkyl-2-acetylglycerophosphocholine Esterase
• PLA2G7 protein, human

Topics

• 1-Alkyl-2-acetylglycerophosphocholine Esterase (blood)
• Aged
• Aged, 80 and over
• Ankle Brachial Index
• Atherosclerosis (diagnosis, enzymology, ethnology, physiopathology)
• Biomarkers (blood)
• Brachial Artery (diagnostic imaging, physiopathology)
• Carotid Arteries (diagnostic imaging)
• Endothelium, Vascular (diagnostic imaging, physiopathology)
• Female
• Humans
• Immunoenzyme Techniques
• Linear Models
• Male
• Middle Aged
• Phospholipases A2 (blood)
• Predictive Value of Tests
• Prospective Studies
• Radiometry
• Risk Assessment
• Risk Factors
• Ultrasonography
• United States (epidemiology)
• Vasodilation