Critical comparison of diffuse reflectance spectroscopy and colorimetry as dermatological diagnostic tools for acanthosis nigricans: a chemometric approach.

Abstract

Quantification of skin changes due to acanthosis nigricans (AN), a disorder common among insulin-resistant diabetic and obese individuals, was investigated using two optical techniques: diffuse reflectance spectroscopy (DRS) and colorimetry. Measurements were obtained from AN lesions on the neck and two control sites of eight AN patients. A principal component/discriminant function analysis successfully differentiated between AN lesion and normal skin with 87.7% sensitivity and 94.8% specificity in DRS measurements and 97.2% sensitivity and 96.4% specificity in colorimetry measurements.

• Authors: Suneetha Devpura, Bensachee Pattamadilok, Zain U Syed, Pranita Vemulapalli, Marsha Henderson, Steven J Rehse, Iltefat Hamzavi, Henry W Lim, Ratna Naik
• Journal: Biomedical optics express (Biomed Opt Express) Vol. 2 Issue 6 Pg. 1664-73 (Jun 01 2011) ISSN: 2156-7085 [Electronic] United States
• PMID: 21698027 (Publication Type: Journal Article)