[Efficacy of prostaglandin derivatives and mucoprotective drugs in treatment and prevention for NSAIDs-induced ulcer].

Abstract

Deficiency of prostaglandins (PGs) by non-steroidal anti-inflammatory drugs (NSAIDs) causes a loss of gastroduodenal mucosal integrity, leading to development of ulceration. PG derivatives such as misoprostol and enprostil have been proven effective in prevention and treatment of NSAIDs-induced gastroduodenal ulcers. Although side effects such as diarrhea limit the use of PG derivatives, the efficacy of these drugs in NSAIDs-induced injuries is approximately equal to that of proton pump inhibitors. Mucoprotective drugs such as rebamipide also have been reported to be effective for prevention of NSAIDs-induced ulcers. Since misoprostol and some mucoprotective drugs can prevent NSAIDs-induced small intestinal injuries, these drugs, especially misoprostol, should be used as first-line therapy for NSAIDs-induced gastrointestinal injuries with attention paid to the side effects.

• Authors: Yoshiko Fujikawa, Toshio Watanabe, Kazunari Tominaga, Yasuhiro Fujiwara, Hiroyuki Sato, Tetsuo Arakawa
• Journal: Nihon rinsho. Japanese journal of clinical medicine (Nihon Rinsho) Vol. 69 Issue 6 Pg. 1039-43 (Jun 2011) ISSN: 0047-1852 [Print] Japan
• PMID: 21688624 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Prostaglandins
• Misoprostol
• Enprostil

Topics

• Anti-Inflammatory Agents, Non-Steroidal (adverse effects)
• Enprostil (therapeutic use)
• Humans
• Misoprostol (therapeutic use)
• Peptic Ulcer (chemically induced, drug therapy, prevention & control)
• Prostaglandins (therapeutic use)