Abstract | BACKGROUND: METHODS: We studied 950 men and women, aged 60 years and older, who attended a research clinic visit where a medical history and examination were performed, and blood for cardiovascular disease risk factors and NT-proBNP levels were obtained. Three cognitive function tests were administered: the Mini Mental State Examination (MMSE), Trail-Making Test B (Trails B), and Category Fluency. RESULTS: Participants with high NT-proBNP levels (≥450 pg/mL; n=198) were older and had a higher prevalence of coronary heart disease (12% vs 30%), and stroke (5% vs 11%; P≤.001 for both). In unadjusted analyses, all 3 cognitive function test scores were significantly associated with NT-proBNP levels (P<.001). After adjusting for age, sex, education, hypertension, body mass index, exercise, alcohol use, smoking, low density lipoprotein cholesterol, creatinine clearance, and previous cardiovascular disease, elevated NT-proBNP levels remained independently associated with poor cognitive performance on MMSE (odds ratio [OR] 2.0; 95% confidence interval [CI], 1.1-3.6; P=.02) and Trails B (OR 1.7; 95% CI, 1.2-2.7; P=.01), but not Category Fluency (OR 1.4; 95% CI, 0.9-2.2; P=.19). Results were unchanged after excluding the 6% of participants with a history of stroke. CONCLUSIONS:
NT-proBNP levels were strongly and independently associated with poor cognitive function in community-dwelling older adults.
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Authors | Lori B Daniels, Gail A Laughlin, Donna Kritz-Silverstein, Paul Clopton, Wei-Chung Chen, Alan S Maisel, Elizabeth Barrett-Connor |
Journal | The American journal of medicine
(Am J Med)
Vol. 124
Issue 7
Pg. 670.e1-8
(Jul 2011)
ISSN: 1555-7162 [Electronic] United States |
PMID | 21683832
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- Peptide Fragments
- pro-brain natriuretic peptide (1-76)
- Natriuretic Peptide, Brain
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Topics |
- Aged
- Aged, 80 and over
- Biomarkers
(blood)
- Cardiovascular Diseases
(blood)
- Cognition
- Cognition Disorders
(blood, etiology)
- Confounding Factors, Epidemiologic
- Diabetes Complications
(blood)
- Female
- Humans
- Independent Living
- Logistic Models
- Male
- Middle Aged
- Natriuretic Peptide, Brain
(blood)
- Odds Ratio
- Peptide Fragments
(blood)
- Predictive Value of Tests
- Psychiatric Status Rating Scales
- Research Design
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