Recurrent tubulointerstitial nephritis and uveitis syndrome in a renal transplant recipient.

Abstract

We report for the time a patient with recurrence of tubulointerstitial nephritis and uveitis (TINU) following renal transplantation. Our patient was diagnosed at the age of 8 years and, despite treatment with systemic steroids, developed established renal failure. At the age of 17 years, he underwent a live-related donor renal transplant. Immunosuppression included tacrolimus, mycophenolate mofetil and prednisolone. Having had normal renal function for 3 years after transplantation, he developed uveitis and decline in the graft function. A biopsy of the allograft demonstrated recurrent granulomatous interstitial nephritis. The recurrence of TINU following transplantation suggests a role for circulating autoantibodies in the disease pathology.

• Authors: Isioma Onyekpe, Mohan Shenoy, Helen Denley, Hany Riad, Nicholas J A Webb
• Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (Nephrol Dial Transplant) Vol. 26 Issue 9 Pg. 3060-2 (Sep 2011) ISSN: 1460-2385 [Electronic] England
• PMID: 21673077 (Publication Type: Case Reports, Journal Article)

Chemical References

• Autoantibodies
• Immunosuppressive Agents

Topics

• Autoantibodies (blood)
• Child
• Humans
• Immunosuppressive Agents
• Kidney Transplantation (adverse effects)
• Male
• Nephritis, Interstitial (complications, pathology, therapy)
• Recurrence
• Syndrome
• Transplantation, Homologous
• Treatment Outcome
• Uveitis (complications, pathology, therapy)