Time-dependent changes in the plasma amino acid concentration in diabetes mellitus.

Abstract

We investigated longitudinal change in the amino acid (AA) profile in type 1 diabetes mellitus (DM) using AKITA mice, which develop DM as a result of insulin deficiency. The plasma concentrations of valine, leucine, isoleucine, as well as the total branched chain amino acids, alanine, citrulline and proline, were significantly higher in the diabetic mice. We show that the degree and timing of the changes were different among the plasma amino acid concentrations (pAAs) during the development of type 1 DM.

• Authors: Taiga Mochida, Takayuki Tanaka, Yasuko Shiraki, Hiroko Tajiri, Shirou Matsumoto, Kazutaka Shimbo, Toshihiko Ando, Kimitoshi Nakamura, Masahiro Okamoto, Fumio Endo
• Journal: Molecular genetics and metabolism (Mol Genet Metab) Vol. 103 Issue 4 Pg. 406-9 (Aug 2011) ISSN: 1096-7206 [Electronic] United States
• PMID: 21636301 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Inc. All rights reserved.

Chemical References

• Amino Acids
• Amino Acids, Branched-Chain
• Blood Glucose
• Insulin
• Isoleucine
• Leucine
• Alanine

Topics

• Alanine (blood)
• Amino Acids (blood)
• Amino Acids, Branched-Chain (blood)
• Animals
• Blood Glucose (metabolism)
• Diabetes Mellitus, Type 1 (blood, metabolism)
• Insulin (blood)
• Isoleucine (metabolism)
• Leucine (blood)
• Longitudinal Studies
• Mice
• Mice, Inbred Strains